Main / World / MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection

MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection

By Jun 30, 2016

Blanié, Sophie and Gelfi, Jacqueline and Bertagnoli, Stéphane and Camus-Bouclainville, Christelle MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection. (2010) Virology Journal, vol.7 (n°56). ISSN 1743-422X

Angelman Syndrome
When Matthew was first diagnosed 22 years ago, there was very small information and support for sufferers and their families. Kerri's son Matthew was the second child in South Australia to be diagnosed with Angelman syndrome.

Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus). Like all poxviruses, MYXV is known for encoding multiple proteins that regulate cellular signaling pathways. Among them, four proteins share the same ANK/PRANC structure: M148R, M149R, MNF (Myxoma Nuclear factor) and M-T5, all of them described as virulence factors. This family of poxvirus proteins, recently identified, has drawn considerable attention for its potential role in modulating the host ubiquitin-proteasome system during viral infection. To date, many members of this novel protein family have been shown to interact with SCF components, in vitro.

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